Systems biology thought experiments in human genetics using artificial life and grammatical evolution
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gp-bibliography.bib Revision:1.8010
- @InProceedings{white:2004:AL,
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author = "Bill C. White and Jason H. Moore",
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title = "Systems biology thought experiments in human genetics
using artificial life and grammatical evolution",
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booktitle = "Artificial Life {XI} Ninth International Conference on
the Simulation and Synthesis of Living Systems",
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year = "2004",
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editor = "Jordan Pollack and Mark Bedau and Phil Husbands and
Takashi Ikegami and Richard A. Watson",
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pages = "581--586",
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address = "Boston, Massachusetts",
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month = "12-15 " # sep,
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publisher = "The MIT Press",
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keywords = "genetic algorithms, genetic programming, grammatical
evolution",
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ISBN = "0-262-66183-7",
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URL = "http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=6278776",
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DOI = "doi:10.7551/mitpress/1429.003.0098",
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size = "6 pages",
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abstract = "A goal of systems biology and human genetics is to
understand how DNA sequence variations impact human
health through a hierarchy of biochemical, metabolic,
and physiological systems. We present here a
proof-of-principle study that demonstrates how
artificial life in the form of agent-based simulation
can be used to generate hypothetical systems biology
models that are consistent with pre-defined genetic
models of disease susceptibility. Here, an evolutionary
computing strategy called grammatical evolution is used
to discover artificial life models. The goal of these
studies is to perform thought experiments about the
nature of complex biological systems that are
consistent with genetic models of disease
susceptibility. It is anticipated that the utility of
this approach will be the generation of biological
hypotheses that can then be tested using experimental
systems.",
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notes = "ALIFE9",
- }
Genetic Programming entries for
Bill C White
Jason H Moore
Citations