An Immune-Evolutionary Algorithm for Multiple Rearrangements of Gene Expression Data

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@Article{deSousa:2004:GPEM,

• author = "Janaina S. {de Sousa} and Lalinka {de C. T. Gomes} and George B. Bezerra and Leandro N. {de Castro} and Fernando J. {Von Zuben}",
• title = "An Immune-Evolutionary Algorithm for Multiple Rearrangements of Gene Expression Data",
• journal = "Genetic Programming and Evolvable Machines",
• year = "2004",
• volume = "5",
• number = "2",
• pages = "157--179",
• month = jun,
• keywords = "genetic algorithms, genetic programming, gene expression, microarray, artificial immune systems, clustering, evolutionary algorithms",
• ISSN = "1389-2576",
• DOI = "doi:10.1023/B:GENP.0000023686.59617.57",
• abstract = "Microarray technologies are employed to simultaneously measure expression levels of thousands of genes. Data obtained from such experiments allow inference of individual gene functions, help to identify genes from specific tissues, to analyse the behaviour of gene expression levels under various environmental conditions and under different cell cycle stages, and to identify inappropriately transcribed genes and several genetic diseases, among many other applications. As thousands of genes may be involved in a microarray experiment, computational tools for organising and providing possible visualisations of the genes and their relationships are crucial to the understanding and analysis of the data. This work proposes an algorithm based on artificial immune systems for organizing gene expression data in order to simultaneously reveal multiple features in large amounts of data. A distinctive property of the proposed algorithm is the ability to provide a diversified set of high-quality rearrangements of the genes, opening up the possibility of identifying various co-regulated genes from representative graphical configurations of the expression levels. This is a very useful approach for biologists, because several coregulated genes may exist under different conditions.",
• notes = "Special Issue on Biological Applications of Genetic and Evolutionary Computation Guest Editor(s): Wolfgang Banzhaf , James Foster

  Department of Computer Engineering and Industrial Automation, State University of Campinas (Unicamp), CP. 6101, Campinas, SP, 13083-970, Brazil",

}

Genetic Programming entries for Janaina S de Sousa Lalinka de C T Gomes George B Bezerra Leandro Nunes de Castro Fernando Jose Von Zuben

Citations