Spatial localization of traveling neural activities induced by curved cortical surface geometry : A pre-pattern theory for brain wiring and folding

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@PhdThesis{Horibe:thesis,

• author = "Kazuya Horibe",
• title = "Spatial localization of traveling neural activities induced by curved cortical surface geometry : A pre-pattern theory for brain wiring and folding",
• school = "Department of Biological Science, The University of Osaka",
• year = "2021",
• address = "Japan",
• keywords = "genetic algorithms, genetic programming, human fetal development",
• URL = "https://ir.library.osaka-u.ac.jp/repo/ouka/all/85278/32153_Dissertation.pdf",
• DOI = "doi:10.18910/85278",
• size = "66 pages",
• abstract = "On the curved surfaces of living and nonliving materials, excitable waves resulting from chemical and electrical activities widely appear to perform some functions. On the human fetal brain surface, spontaneous neural activities occur and spatially transmit over the surface. A candidate origin of the excitable waves is the subplate neuron. The subplate neuron forms a uniform component (subplate component) that is tangentially continuous throughout the whole brain. Spontaneous neural activities in subplate components have been suggested to support when and where brain folding and nerve fiber wiring occur during the fetal period, but the mechanisms are largely unknown. In this study, to confirm whether the geometry of the uniform component controls the direction of neural activities and if yes, how the fetal brain geometry causes neural activity bias, I numerically simulated an excitable wave on a curved surface. Then, I found that a surface geometry induces bending and splitting of an excitable wave. Moreover, I predict the bending and splitting of the wave using the shortest paths. Furthermore, I find a spatial localization of neural activities is induced by the fetal brain surface from the shortest paths. This spatial localization corresponds with the position where a neural fiber matures after the developmental stage. Moreover, the direction of elongation sulcus during development corresponds with the displacement of spatial localization of neural activities. In summary, a neural activity that is spatially localized according to the surface geometry of the brain can serve as a pre-pattern for supporting the brain folding and wiring of nerve fibers.",
• notes = "In English",

}

Genetic Programming entries for Kazuya Horibe

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